Can any one suggest rat or other experimental animals model for studying the Anti-obesity effects of medicinal plants extracts?
Dear Bashier,
To study the anti-obesity effect there's many experimental models in vivo...
Experiments reported by Smith (1927, 1930) showed that administration of chromic acid into the suprasellar region of rats with lesion of the hypothalamus induced obesity in rats (Bomskov 1939). Also the injection of monosodium glutamate to newborn rats, leads rats to develop obesity by destructing the ventromedial hypothalamic and arcuate nuclei (Lordon et al., 1986).
Furthermore, using genetic models seem to be good to test the anti-obesity effect of medicinal plants, all the previous models their study and extrapolation in humans remains too limited. Thus the simpliest obesity-induction model and the most closely to human being is the hypercaloric diet model, by adding fats and carbohydrates caloric values attain about 5.4 Kcal/g which is high and susceptible to induce obesity (see Naderali et al.)
In order to provide an idea of these obesity models i suggest you the following paper :
Hi, the most common diabetes model i've ever seen in lots of articles is streptozocin-induced diabetic model in animals, but i've not had any experience in this field.There is a link here may help you:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417415/
Dear Bashier,
To study the anti-obesity effect there's many experimental models in vivo...
Experiments reported by Smith (1927, 1930) showed that administration of chromic acid into the suprasellar region of rats with lesion of the hypothalamus induced obesity in rats (Bomskov 1939). Also the injection of monosodium glutamate to newborn rats, leads rats to develop obesity by destructing the ventromedial hypothalamic and arcuate nuclei (Lordon et al., 1986).
Furthermore, using genetic models seem to be good to test the anti-obesity effect of medicinal plants, all the previous models their study and extrapolation in humans remains too limited. Thus the simpliest obesity-induction model and the most closely to human being is the hypercaloric diet model, by adding fats and carbohydrates caloric values attain about 5.4 Kcal/g which is high and susceptible to induce obesity (see Naderali et al.)
In order to provide an idea of these obesity models i suggest you the following paper :
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