What is the most progressive tumor bearing mice model that was widely known, in which the tumorgensis is very quick? Or what is the most progressive tumor cell line?
Dear Zhanguo Yue.
It is tricky giving you a simple and direct answer because it really depends on the carcinoma like Ling Tian said.
Just make sure there aren't any problematic point mutations in the strain you selects.
We used to use immunocompromised SCID/nude mice to avoid wanted immune responses to our lentivirus/adenovirus injections. Several inflammation spots were confused to tumor formation regions.
However, for some long term genetic studies I used C57/Bl6 and 129Sv mice. For instance, one one my studies was related for kidney development. When I knocked-out one gene in the C57/Bl6 mice, the mice would have 2 or 1 kidneys. With the 129Sv none would form due to the gene knock-out.
C57/B16 melanoma model is very aggressive and you can develop very easily.
Yes. It depends on the carcinoma type.
This is what I got.
For melanoma: A 375 in nude mice or B16F10 in C57 mice
For beast cancer: MDA-MB-231 in nude mice or 4T1 in BalB/c mice
Correct? Any other progressive models?