The simplest explanation that has been given till now is that the silver NPs create ROIs or Reactive oxygen species in the cellular membrane that can be genotoxic in nature. There is actually a paper from our centre talking about the same Genotoxicity has been done via comet assay.

http://www.ncbi.nlm.nih.gov/pubmed/22178963

The simplest explanation that has been given till now is that the silver NPs create ROIs or Reactive oxygen species in the cellular membrane that can be genotoxic in nature. There is actually a paper from our centre talking about the same Genotoxicity has been done via comet assay.

http://www.ncbi.nlm.nih.gov/pubmed/22178963

Thank Yadavalli, Could u plz send me the full article

Dear Amal,

I agree with Tejabhiram's answer and I appreciate it but I would like to differ a bit. Well you see, production of ROS is not the only explanation but the mechanism involved in the anti-cancer potentiality of the silver nanoparticles synthesized in a biogenic manner also act through multiple pathways. I have worked on the AgNPs (Synthetic) on colon cancer model and studied the detailed mechanism. You can refer my paper.

Here is the link: http://www.ncbi.nlm.nih.gov/pubmed/23514434.

Feel free to discuss.

Regards

Dear Amal,

Another reason might be effect of these particles directly on PI3/Act and caspase signaling pathway. AgNP can inhibit the PI3/AKT phosphorylation and inhibit cell survival and vascular permiability and activate caspase 9 and 3 and induce apoptosis.

Http://www.ncbi.nlm.nih.gov/pubmed/19686832

We studied metal nanoparticles isolated from human and animal blood. We obseved the presence of zinc, copper, silver, gold, among other metal nanoparticles. We found that these nanoparticals are about 1-2 nm in diameter and composed of 50-400 atoms. These endogenous metal nanoparticles are capable of killing cancer cells at fractions of nM. The engineered nanoparticles of Zn and Cu also kill cancer cells, but spare normal cell. We published these results in to articles (attached).