Today I came across a 5,224 amino acid long protein, from Drosphila, that has homologs in other insects. http://www.ncbi.nlm.nih.gov/nuccore/194894863
It is some sort of fancy zinc finger protein "RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C". I have no idea what it does, but it made me wonder if it might be one of the largest known (or predicted by bioinformatics) proteins.
Brian Thomas Foley
Wow. 26,000 amino acids in Titin: http://www.ncbi.nlm.nih.gov/nuccore/1212991
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