Zeb1 is antagonized with Rb which controls the epithelial cell-to-cell adhesion. According to several papers, depletion of Zeb1 results in the active transcription of CDH1, encoding E-cadherin. Further, simultaneous ablation of Zeb1 and Zeb2 leads to more enhanced expression or ectopic expression of E-cadherin (Figure 6-C of J Biol Chem. 2012 Mar 9;287(11):7896-906). What is the difference between Zeb1 and Zeb2 in terms of the epithelial-to-mesenchymal transition (EMT)? What is the molecular pathway of the interaction of Zeb2 with Zeb1?  After all, ZEB1 mutations are associated with posterior corneal dystrophy, and ZEB2 mutations were reported to be associated with Hirschsprung (HSCR) disease.

http://www.jbc.org/content/287/11/7896/F6.expansion.html