I try to understand the different function of PP1 different catalytic subunits (beta and gamma) in tumor development and suppression. We know that PP1 regulates a few hundreds of different proteins which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. We have developed a cancer drug which induces apoptosis in tumor cells, but after the treatment we found that PP1 beta is down regulated in contrast to gamma subunits which is up regulated. I hope some of you who study PP1 could discuss these results. 

thanks