I try to understand the different function of PP1 different catalytic subunits (beta and gamma) in tumor development and suppression. We know that PP1 regulates a few hundreds of different proteins which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. We have developed a cancer drug which induces apoptosis in tumor cells, but after the treatment we found that PP1 beta is down regulated in contrast to gamma subunits which is up regulated. I hope some of you who study PP1 could discuss these results.
thanks
Thanks Andrey for your comment. Indeed these results are very intersecting and could be very essential project but unfortunately we don't have either time or possibility to study that. Of course we welcome all kind of collaborations and exchange knowledge.
I hope some researcher who are studying PP1 could comment these results.
Thanks again
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