Hello! What are the oldest literary sources you know that would mention pharmaceutical salts? I am aware of the first cocrystal [benzoquinone + hydroquinone] (1:1) investigated in 1844, but I could not find any mention of the first (or even the first described) pharmaceutical salt (Wohler, F. Untersuchungen über das Chinon / F. Wohler // Ann. Chem. Pharm. – 1844. – V. 51. – P. 145-163). If you know of such sources, please share them. Thanks in advance
Pharmaceutical salt is an ionizable drug that has been combined with a counter-ion to form a neutral complex
I don't know the first published reference, but sodium salicylate is pretty old as well (19th century) https://link.springer.com/content/pdf/10.1007/BF01450953.pdf
Dear Gabriel Silva Marques Borges ! Thanks a lot for this paper. I was also able to find a few salts from the 19th and 20th century: sodium birbiturate and sulfamidochrysoïdine hydrochloride. However, sodium salicylate would be the oldest known to us. Thanks again for this information!
As far as I understand, at the turn of the 19th and 20th centuries, there were enough chlorides and sodium salts of the API. However, it is not yet clear when salts with organic counterions began to be used. Perhaps someone has such information?
Interesting situation. As soon as I write a question here, I immediately find the answer. Here are some papers on pharmaceutical salts (responding to my comment above): 1) 10.1016/j.ijpharm.2021.120993; 2) 10.1016/j.jddst.2021.102913
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