The possible benefit from the use of Statins in the treatment of Ankylosing Spondylitis (AS) is based on the following premises:

A. AS is associated with increased risk of cardiovascular disease.

B. Atherosclerosis is increasingly recognized as an inflammatory process.

C. Statins have proven anti-inflammatpry effects:

1.     Inhibition of leucocyte–endothelial adhesion

2.     Inhibition of production and reduced chemoattraction of monocyte chemotactic protein-1

3.     Reduced interleukin-6 (IL 6), IL-8 and IL-1β production

4.     Statins decrease T cell activation

But we still need well-designed studies to prove that statins do have a role in the treatment of AS.    

Thanks a lot Majda for your  answer.Best regards

Unfortunately, there are still no good  evidence-based studies that prove the beneficial effects of statins in AS.

Thanks a lot Panayot for your answer.