If expanding the ring structure from 5 member to 6 or 7 , then what is the effect of ring size on the MDR, bioavailability and cytotoxicity in general.
Ring size is generally correlated with lipophilicity. An increase in the ring size from 5 to 7 will increase the lipophilicity of the molecule.
If the drug is hydrophilic and you increase the ring size contained in the drug, the bioavailability will be increased and vise versa.
In the above mentioned case if your drug is hydrophilic anti-cancer agent and you increase the ring contained in the molecule the cytotoxicity will be increased (positive result).
There is NO correlation between MDR and ring size.
I hope this information will be helpful.
Dear Rafik Karaman,
Thank you so much for the information. Can you please provide me the links to the article having such information.
Regards
This is from many articles that I have read and wrote.
My field is improving bioavailability of drugs.
You can get into my profile in Research Gate.
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