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Questions related from Ramit Singla
A synthetic compound has a impressive ER-alpha binding affinity, comparable to the clinical standard but feeble anti-proliferation activity on breast cancer cells line. What are the possible...
28 January 2018 4,996 2 View
After the dehydration using DCC (N,N'-dicyclohexylcarbodiimide) in DCM, I have a single product after confirming from 2D TLC. How could i remove the DCC from the product. Aqueous workup I think...
24 March 2016 4,766 11 View
after the construction of the homology model of GPCR, how can I determine the model is in active conformation of inactive conformation. What is the possible criterios/methods to determine this...
07 November 2015 9,132 0 View
If expanding the ring structure from 5 member to 6 or 7 , then what is the effect of ring size on the MDR, bioavailability and cytotoxicity in general.
18 October 2015 4,705 3 View
has any one seen a change in the abundance of C-13 during the winter and summer season, is it possible to observe relatively high abundance of C-13 in a compound during winter as compared to...
19 February 2015 2,291 5 View
many a time we encounter reaction involving aniline. How to remove this reactant when the difference between of RF between this and of the product is very small, almost they overlap each other on...
12 December 2014 5,945 18 View
Benzyl bromide and the product formed are soluble in organic phase like ethyl acetate, the excess of benzyl bromide present in the product may lead to its deterioration. How does one separate...
01 October 2014 1,196 34 View
In MD simulation we have a numerous options of membrane like POPC, DPPC; water system like TIP4P, TIP3P and boundary condition like orthorhombic.
26 March 2014 3,090 2 View
The LogP o/w value determines whether the drug would pass from the membrane and get close to the target site, and the main prime objective is get a drug which have an optimum LogP o/w value. Is...
26 March 2014 2,829 1 View
