Hello, I want to induce infertility in rats, I want to know the dosage of gossypol to use and how long I will administer the gossypol to achieve infertility. Also, does gossypol induce infertility in female rats?
Dear
25 mg per kg Bw for one spermatogenesis cycle
This confirmed anti-fertility parameters
thanks,
the maximum tolerated dose of gossypol in rats is reported to be 15-20 mg/kg with this dose inducing infertility within 5 weeks. (Beaudoin AR, 1985)
5 - 10mg/kg of gossypol daily for 12 weeks to induce infertility in rat. ( M.C. Chang etat., 1980).
5 _10mg/ kg of gossypoldaily
5 or 10 mg/kg daily for 12 weeks.
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