Is there scientific evidence that proves that the presence of N-acyl homoserine lactone can account for the bacterial biofilm population?..
Hello Chioma Benson Ubah
The answer is yes. But a short description would be necessary for better understanding.
During the process of biofilm formation microorganisms have the ability to communicate with each other through quorum sensing (QS). QS regulates the metabolic activity of planktonic cells, and it can induce microbial biofilm formation and increase virulence. Homoserine lactones are a class of important cellular signaling molecules involved in QS and acyl homoserine lactone-dependent QS system is used primarily by gram-negative bacteria.
One can develop strategies to target the biofilm and biofilm-producing bacteria, and the quorum-sensing signal profiling of bacterial strains could serve as a biomarker in screens to identify agents that interfere with biofilm development.
You may want to refer to the articles attached below for more information.
Article Singh PK, Schaefer AL, Parsek MR, Moninger TO, Welsh MJ, Gre...
Article Communication is the key: biofilms, quorum sensing, formatio...
Article Quorum Sensing Inhibitors as Anti-Biofilm Agents
Best.
Malcolm Nobre Thank you for your response, I will surely check-up those articles.