I have interest in monocyte-macrophage lineage and examining the behavior in the TME.
I know that MDSCs can be granulocytic or monocytic, but do monocytic MDSCs represent the same or an overlapping group as TAMs?
Would love both a verbal description differentiating their behavior and the flowcytometry markers used to distinguish/define them if possible.
Finding it very hard to distinguish from the literature due to inconsistencies in cell markers and terminology.
MDSCc are precursor of TAM and TAN. MDSC migrate from BM. This nice paper describe them well:
http://cancerres.aacrjournals.org/content/70/14/5728.short
From my experience with mouse MDSC and TAMs.
I think MDSC are well defined by markers as CD11b+GR1+ or CD11b+Ly6Chi. There are others makers in the literature but among all of them, I think these represent a good putative choice. Besides, TAMs, are a bit more complicated to get them. Surely, the marker CD11b overlaps between both populations but there are more specific markers from the alternatively (M2) activated macrophages that are not linked to MDSC. An example are the following; CD163, Arg1, Ym1 or Fizz1.
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