What is the difference between Comparator and Control in RCT?

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Enric Aragonès

Responses and examples reported by Elmer are clear and understandable. Whenever you use these concepts (control, comparator, active control, placebo control...) you must define them explicitly.

Dimitrios Zardavas

comparators would be the different therapeutic strategies assessed and compared head-to-head within the context of an interventional trial. your 'control' in that case would be the comparator that should be viewed as the till now established therapeutic strategy for the population of interest.

best

Onkar Rathod

Just to rearrange the text:

A comparator drug/intervention/treatment is an already approved and licensed drug/intervention/treatment that is currently being used on the market in clinical practice. Control can be a Placebo treatment or No treatment at all, or a treatment arm not receiving active drug treatment but put in the similar/controlled conditions defined by the clinical trial protocol.