Any one who could suggest on "why rats are used in OGTT but mice for hypoglycemic test in most of animal based studies to investigate the antidiabetic potentials of medicinal plants?"
I do not know enough about plant medicine but in the field of studying diabetes from other perspectives, both rodent models have been used for glucose tolerance test (GTT). There are more obese mice models than there are rat models so it makes sense that one may find more reports using mice when studying various treatments to manage type 2 diabetes.
Depending on the nature of a study, the size of the experimental animal also comes into play. If a study involves something beyond measurement of glucose levels alone (as is the case with GTT), such as simultaneous measurements of one (insulin) or multiple hormones, need of larger blood volumes required for such measurements creates a practical limitation, given that a mouse is far smaller than rat and consequently, one can only draw a small amount of blood/day (usually 5% of total blood volume but certainly no more than 8%).
I do not know enough about plant medicine but in the field of studying diabetes from other perspectives, both rodent models have been used for glucose tolerance test (GTT). There are more obese mice models than there are rat models so it makes sense that one may find more reports using mice when studying various treatments to manage type 2 diabetes.
Depending on the nature of a study, the size of the experimental animal also comes into play. If a study involves something beyond measurement of glucose levels alone (as is the case with GTT), such as simultaneous measurements of one (insulin) or multiple hormones, need of larger blood volumes required for such measurements creates a practical limitation, given that a mouse is far smaller than rat and consequently, one can only draw a small amount of blood/day (usually 5% of total blood volume but certainly no more than 8%).
oGTT are harder in mice since they have a smaller mouth, but are not particularly difficult. You can't use a rat gavage needle on a mouse, it is too large. We routinely perform both oral and IP GTT's on mice. As mentioned by Tausif, if you are planning on measuring more then just glucose you will get into a blood volume issue with mice faster than with rats.
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