Depends really, dexamethazone is doesnt bind to the DNA rather in the glucocorticoid receptor homodimer which is an transcriptional regulator, to identify the transcription factor binding regions u need to do a CHIP-seq and expression a RNA-seq. Statistical try R, has plenty of packages like 'chipseq', and 'DEseq', 'edgeR' for RNA seq. Hope that answers the question

I just want to check if these sequence bind to miRNA promoter ?

The GRE can vary - the only way to be sure that the glue -R binds to your miR cluster promoter is to do ChIP. Software will only predict the possibility.

Good Luck

G

Granz Gallagher thank you

You may try to use existing glucocorticid receptor ChIP-seq datasets in various cell lines and liver to assess whether GR bind to the to genomic region for your interest. However, this may require help from an expert bioinformatician.

Thanks Rucha