I am actually trying to load Schizophyllan, which is a beta-glucan, into polycaprolactone solution, which I will later use for electrospinning. PCL has been dissolved in 7:1 (v/v) chloroform and methanol at a concentration of 8 wt%/volume. Schizophyllan is soluble in water. How do I load this into the polymer solution? The problem that occurs here is that beta glucan is immiscible in chloroform and methanol, and PCL is immiscible in water. When I mix the two solutions, i.e Schizophyllan and PCL solution, precipitates are formed. What could be an another alternative?
Dear Ananth
PCl can also be electrospun in water miscible solvents such as Acetone or THF.
If you prefer to spin in CHCl3/MeOH, try if you can dissolve/avoid precipitation by adding PCL into the mixture of water/drug/CHCl3/MeOH.
Dear Marc
The drug is not miscible in CHCl3. So I wouldanyhow get the precipitates if I try to dissolve the drug in chloroform.
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