Does anyone have experience in this field? I assume you start by finding an upregulated cell surface receptor? Any information would be greatly appreciated.
Hi,
if you do not have a receptor target, probably the "Phage display peptide library" it may help you. You will identify custom-designed peptide(s) that will target your cancer cells (by interacting with a surface receptor).
https://www.neb.com/products/protein-tools/phage-display
http://www.genscript.com/peptide-library-and-cancer-research.html
Hope this may help you. Good luck.
Regards,
Daniele
Totally agree, Phage display peptide technology is one of the best options. Not to complex but labor-intense. Other options like in silico predictions or bibliography reviewing could fit your objectives depending on the research context.
I am not sure what is your aim, but perhaps you can take advantage of some of the many sequences that have already been identified. Take a look at:
Svensen, N., Walton, J. G. A., Bradley, M. (2012) Peptides for cell-selective drug delivery. Trends Pharm. Sci. 33, 186–192.
Enbäck, J., Laakkonen, P. (2007) Tumour-homing peptides: tools for targeting, imaging and destruction. Biochem. Soc. Trans. 35, 780–783.
Srinivasarao, M., Galliford, C. V., Low, P. S. (2015) Principles in the design of ligand-targeted cancer therapeutics and imaging agents. Nat. Rev. Drug Discov. 14, 203–219.
Laakkonen, P., Vuorinen, K. (2010) Homing peptides as targeted delivery vehicles. Integr. Biol. 2, 326–337.
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