Membrane proteins are very essential parts of the cell. They usually control the influx and efflux of materials. Determining the exact function i.e. exact mechanisms can be very helpful for research like drug discovery. Can computational methods aid in this process?
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1. Determine the primary structure.
2. Determine or predict the secondary, tertiary, and quaternary structure.
3. Search for functional information available for homologous structures.
4. Predict the function based on the available information.
5. Test the prediction computationally by exploring, both qualitatively and quantitatively, the functionally relevant bio(macro)molecular interactions.
6. Confirm the prediction experimentally.
If its a known protein, you could search for protein-protein interactions to get an idea of what it interacts its with (String database etc) If there is a PDB structure/sequence you could investigate its homology.
https://string-db.org
Hi Araf,
Make predictions based on the functional information of homologous proteins or protein families. If there is no homologous protein, some conserved motifs or functional domains can be studied.