Any suggestions? Perhaps in NaOH and the neutralize to pH 7. I need the pH to be around 7 in the final solution.
You posted a very bad formulated question !! Why?
You wrote a day ago :
Perhaps in NaOH (what a kind of NaOH) and then neutralize to pH 7
(With what an acid ?HCl or H2SO4?)
. I need the pH to be around 7 in the final solution. (for pH 7, you must do a titration!)
Well, what do you want to investigate with p-coumaric acid (pCA)?
Please note that you must determinate the pKa value of pCA (p.e. per UV-Vis/see google) when you work at pH 7.
see:
Article Determination of pK(a) values of some hydroxylated benzoic a...
see:
https://pubchem.ncbi.nlm.nih.gov/compound/p-coumaric_acid#section=MeSH-Entry-Terms
see these links too.
https://pubs.acs.org/doi/abs/10.1021/acs.jced.6b00807?journalCode=jceaax
and
Article Absorption and emission behaviour of trans- p-coumaric acid ...
and
http://oatao.univ-toulouse.fr/1596/1/Salameh_1596.pdf
Please end infos about your research aim!!
It seems that you are NOT FAMILIAR with Google or Google Scholar searches.
JRG
Jean,
Sir, I think your answer is very rude and disrespectful. If you feel that my question is very generalized and you want more information, you should simply ask for it. Insulting an individual's intelligence and using mockery is not helpful for anyone's learning process and I refuse to tolerate it. P.S. I am very familiar with Google and also familiar with Google scholar.
Sorry but I am not disrespectful. Answerers need always very precise questions with infos. Your question was too vague.
JRG
How about DMSO to see if it is soluble first? With D6DMSO one could get a proton NMR spectrum if the instrument locked on to the Deuterium. It seems to have a phenol and a carboxylic acid group, which could both be acidic. The titration curve may be irregular with NaOH because both acidic groups are weak acids. Be careful with DMSO because it makes your skin transparent to poisons.
see please:
https://www.researchgate.net/post/Are_p-and_m-coumaric_acids_soluble_in_PBS posted 2years ago
According to Frank' s answer:
cited from :
http://chemistry-chemists.com/N3_2011/U/DMSO-technical_bulletin.pdf
The table below (Table XI) lists the acidities (pKa) values of 132 organic compounds in DMSO, starting with the most acidic protonated pyridine, and ending with the least acidic-propionitrile (10569). The pKa of DMSO is 35 (10411).
Jean,
I apologize for misjudging your intentions and my strong words. I meant no disrespect either. My intent was to dissolve the acid in 1 M NaOH and after forming the sodium salt, neutralize the solution to ~ pH 7 with 1 M HCl. But I have not tried this yet.
Frank, I have already tried DMSO and the compound dissolves very well in DMSO. The problem I am encountering is because the solvent is not compatible with my assay. The protein that I am using is very sensitive to DMSO. I am doing some experiments to test the lowest concentration of DMSO that I can use with my assay.
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