In my laboratory we only have the conditions to use small rodents, rats or mice (or cell lines).
In your opinion, what is the best model for studying the long-term effects of gestational diabetes on the offspring? There is so much diversity of protocols and diets with such different compositions ...
is there any cut off value of blood glucose to say that a rodent is diabetic?
Thank you in advance for sharing your knowledge
Hi
Have a look on this :
http://dx.doi.org/10.1155/2016/9704607
and this :
doi: 10.1152/ajpendo.00425.2013
You may find this interesting:
https://doi.org/10.1210/er.2009-0038
and also these:
https://www.ncbi.nlm.nih.gov/pubmed/19557203
http://www.sciencedirect.com/science/article/pii/S0303720715301751
In humans, GDM occurs most often in the second half of pregnancy and usually disappears after delivery. The issue of disappearance after delivery is generally not investigated and thus not given in published experimental models. i.e., it is not so complicated to induce hyperglycemia associated with impaired lipid metabolism in pregnant rodents, but the question remains what happens after delivery.
katka
Thank you so much for your great suggestions!
Thank you so much Katarina Sebeková to point out that important aspect
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