I agree with Dr C.A Kan that each material can be toxic at certain level. Probably you mean with the word toxicity that the extraction take place in non toxic solution (This is my expectation) so focus only on how to extract the materials you mentioned, and ignore to use the word toxicity. In the first place you gonna to extract food ingredients that are natural sources with low possibility of toxicity. So focus on the extraction methods to give to rats. So my be formulate your question as.
How can I extract purple carrots, hibiscus and mangoes to give to rats?