I prepared Ketoprofen nanosuspension the DSC analysis of the formulas revealed melting point of KP while XRD data showed loss of crystallinity
Dear Aisha Abdo ,
what is the issue?
melting point versus crystallinity?
Do you expect any relation?
By the way; your XRD measurement is related to Ketoprofen as nanosuspension; thus I expect, that you mainly see the dispersing agent in the XRD pattern, but not the KP.
For a crystalline Ketoprofen pattern you may have a look at Fig. 3 of:
Article Influence of polymer ratio and surfactants on controlled dru...
Please imagine a strong broadening of the peaks (because of 'nano-supension') one wolud expect a position of the main peak around 30° but not around 20°.
Liquids*) have XRD pattern like that you presented.
So, to my opinion, any conclusions do not work here.
*) For comparion with your pattern you may take an XRD scan of your 'pure' dispersing agent and figure out the differences...
Best regards
G.M.
"Could DSC data contradict XRD?"
Not if properly interpreted.
If you think DSC melting point = XRD loss of crystallinity, then they may appear to contradict.
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