I want to study IGF-1 effects on mice muscles with accelerated sacropenia.
I see people have tried I/M injections or placing time release pallets of IGF-1 next to the gastrocnemius muscle. Can somebody tell me which one is the more effective method against systemic administration of IGF-1 via I/P or S/C injections?
Also, is there any good link for buying the pallets of injectable IGF-1?
Dear Rizwan,
I can suggest you to check the pioneering research fro Rosenthal and Musaro. I tried a couple of time injecting recombinant IGF-1 intramuscualrly into anterior tibialis without having particular success, in vitro experiments with C2C12 or frwshly isolated satellite mouse cells I used a home made PEG based gel carrying IGF-1, and it works showing bigger myotubes in both cell system.
Good luck
Cesare
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