Many models out there but which is the best for neuroprotection studies? I have some compounds validated using in vitro assays and I am looking for collaborators to test them in other models.
http://www.deltaneuron.com/
We've exposed APP/PS1 AD-transgenic mice to experimental traumatic brain injury (TBI) and found accelerated AD symptom manifestations. We'll be happy to test your compounds in TBI models with AD endpoint outcomes.
hi there,
Well, there are very few AD models with cell death easily detected. 5xFAD mice, 3xTgAD mice (but at very late stages) and the Mice with the Arctic mutation (with is very vascular pathology oriented). We do possess one of those, let me know if you are willing to discuss more.
best
Hi Nat,
I would be interested to know which in vitro assays you used for your preliminary neuroprotection studies. If you have any info or advice, please let me know.
Many thanks
Hi Nat. I agree with Yannick that the main problem with AD models is their lack of neuronal death. However, if you first want to check that your drugs work by reducing amyloid burden, you can use any of the AD models. 5xFAD animals are ok to have quick preliminary results since their pathology stars around 1.5 months, althogh sometimes it's a model too aggresive to be able to see any difference. You can also try with double APP/PS1 (pathology at 6 months) or Tg2576 animals (9-12 months). As suggested before, 3xTgAD animals are a good option because they have some cell death. We have all of these animal models and also type 2 diabetes and prion animals, just in case you want to check whether your drugs also work in other protein misfolding disorders. Best, Ines.
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