We want to delete some genes and study their effects on developmental angiogenesis. However, intraperitoneal injection of tamoxifen at a dosage of 50 ug/g causes mass non-specific embryonic deaths at E12.5/13.5.
Have you tried sub/cut pellets implanted in the neck area?
Brian Telfer No. What is the dosage used? Any protocol to refer to?
thank you
Hi Nathaniel, have a look at the link below if it's any use.
Article Short‐term tamoxifen treatment has long‐term effects on meta...
Hi Nathaniel, this might be more relevant. Cheers B
Article Serum tamoxifen concentrations in the athymic nude mouse aft...
Brian Telfer I will check them out. Thanks
Hey Nath. You can try with food pellets that contain tamoxifen, but probably not the cheapest option.
Cheers ;)
Hello Ramón. Sure, I will try that option also.
Thank you.
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