thank you dear Charles

I think this could be useful

http://www.itb.cnr.it/breastcancer/

Bye,

Luciano

Up to my knowledge , The most widely used tool to investigate the mutation database in breast cancer is the BIC (Breast Cancer Information Core) and in the clinical molecular genetics setting ,the investigators depending on that database as a main tool.

Regards

http://research.nhgri.nih.gov/bic/

It really depends on what question one is trying to answer. To assess pedigrees for likelihood of a BRCA1/2 mutation you can use BOADICEA or BRCAPRO. To interpret mutations is more difficult because the BIC does nor really classify mutations. A consortium called ENIGMA is trying to do that. Mostly it is best to develop ones own bespoke database that can export into programmes like BOADICEA, but answer other questions such as breast cancer survival.

Dear Evans,

Actually this is my problem because i'm studying polymorphisim in AHR and CYP1A1 genes not BRCA1/2 mutation so i have confuse and a pressing need to one database to depend on it.

Thank you very much indeed for you and all who respond my question

Regards