Cancer is a very complex disease which involves many enzymes. The enzymatic targets are increasing dramatically due to the continuous discovery of new key enzymes involved in the cancer cells proliferation. what are the best map to follow to defeat the cancer in its different stages. I think if we discover and know the priority of treatment according to disease phase we can guest the correct treatment. But physician apply treatment by giving classical drugs such as kinase and topoisomerase inhibitors, microtubule stabilizer etc. without knowing the molecular history cancer cells.
Are we so far to determine the disease map to solve the enigma of cancer?
A lot of the 'molecular history' of cancer cells could be "read" from the sequencing of the genomes of the cancer cells. Further characterisation could be obtained from the epigenomic analysis (and global gene expression analysis) of the cancer cells. Personalised medicine would depend on the realtime sequencing of cancer biopsy and interpretation of the output to diagnose the staging of cancer and guide optimum therapy. For an exploration of the state of the art, try The Cancer Genome Atlas (TCGA) : cancergenome.nih.gov
The results of any anti-enzymatic cancer therapy are quite disappointing. Up to now there is now good evidence, that a so called "anti-enzymatic therapy" is helpful. Even the definition of an enzymatic therapy is unclear. Thus I believe, that we can consider an anti-enzymatic therapy at the level of a placebo therapy.
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