We have a substance that potentially reduces the sensation of pain. We want to study it on laboratory animals. We are looking for a way to measure pain in animals.
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test on animal is difficult nowadays in Europ, to measure pain.Also it gives a bad image
You need to wait for a pinfull accident on a person that speaks and tell you the measure of pain on ascale form zero to 10 ; then apply your anesthesant and measure again the pain.
this is what I do for arthrosis pain : I stated clinical tests to measure how my Ticulause cream decreases arthrosis pain
Laboratory animals are used for a model, a representation of a situation. Hence, talking about the painkiller substance you mention. First, it is necessary to define objective of the study, animal experimentation could be mainly necessary if:
Substance is new and safety characteristics for mammals are unknown
Their pharmacological and physiological properties are uncertain
Analgesic effects depend of administration route
Several animal models could be use such as: mice and rats.
If all above mentioned questions and other requested by drugs authority related are already answered properly, maybe it is better to go for a clinical study in voluntary informed patients.
You need compare your substance against a gold standard already use in clinical medicine.
On the other hand, you also should be keep on mind that the substance could be also good for veterinary medicine, in this case animal response is specie depend.
I expérienced double anesthesy on rats ..after ethical commitee..during 8 months..for my burn cream...
Recovery tests were measured by quantity of food eaten in next days and helped me a lot
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