I am currently working on ischemia- reperfusion-induced brain injury in Wistar rats, and as of now we are using Ketamin-Xylazine or low dose of Urethane for inducing anesthesia. I have over heard that these agents could greatly influence the ischemia-reperfusion-induced brain injury and hence looking for better and safe anesthetic agent.
Based on your experience and domain knowledge can any one refer better anesthetic agents for my experiments.
Hi, depends on what you have available. Roughly, pentobarbital, urethane, ketamine? Ketamine is not a true anesthetic despite its large usage, urethane is a little bit tricky and has the advantage of not depressing blood pressure too much; pentobarbital depress blood pressure, respiration and has a direct protective effect on the brain in bad situations. That is the case in your experiment. Do, if you want to use pentobarbital, be aware of that component.
Dear Renaud Trouve,
Thanks for the response. Kindly suggest some suitable agents .
Regards
Vishwanatha
Hello,
Isoflurine is the best anesthetic agent we can use during surgeries which take long time for completion.
I limited my answer to injectables, because gazeous anesthesia is nice but you have to be equipped, ventilate the animal and master all these points. If it is ok for you this is the best solution indeed but they are prerequisite.
Buenas noches
La pregunta parece va dirigida a anestésicos IV, indudablemente la ketamina lleva ventaja sobre otros anestésicos; en mi experiencia el segundo lugar sería para el propofol, luego el tiopental.
Para mejor opinión deberiamos conocer el objetivo de la investigación.
Gracias
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