The insulin secretion in the body of a Type 1 Diabetic is impaired/absent. Is there any insulin secretion in the body for a typical Type 1 Diabetic Patient? If yes then what is the level (typical value)?
The context of the question is that when we simulate the compartmental model of Type 1 Diabetic patient, then is it necessary to include some constant basal value of insulin? But for control problem of blood glucose regulation of Type 1 Diabetes we sometimes assume that the body produce zero insulin.
Summarizing the query, it is that should we include some basal insulin concentration in blood plasma or consider it as zero.
The answer to your question, as it is put, depends on the stage of T1DM along its temporal progression. If you review the literature, you will see that early on in the disease, there are some islets but eventually they are all destroyed.
A C-petide measurement on a specific patient will give you a much better idea as to how much insulin is coming from endogenous remaining islets at a given point.
There is no 'typical' basal insulin level in type 1 DM. It depends on the stage of the disease as at the time of your assessment.
the question is basal plasma insulin concentration -that means it is base value of insulin ,it should be consider as the time interval measurement average ,than we have find the average for the particular patient ,for testing purpose we have to take it as the minimum level like as thres hold value ,for automatic insulin injunction this base level condition is very important
- Badges
- Science topic
- Similar topics
- Medicine
- Disease
- Metabolic Diseases
- Glucose Metabolism Disorders
- Diabetes