You can check other questions concerning this topic on researchgate
https://www.researchgate.net/post/Can_anyone_tell_me_exact_injection_site_to_develop_orthotopic_lung_cancer_in_nude_mice2
https://www.researchgate.net/post/Does_anyone_know_a_good_mice_model_for_lung_cancer
Dear Abeer,
Whenever you are looking for an animal models, please search LAMHDI, the initiative to Link Animal Models to Human DIsease. http://www.lamhdi.org/ For example:
If you search for "lung cancer"- you can further filter your results by mice just by clicking n the link ( "lung cancer" ) species:mouse
Interestingly, I could not find any lung cancer models for rat on this database
I hope this helps.
Good luck!
We used by the past the human A549 non-small-cell lung cancer model orthotopically grafted into immunocompromized mice. This model is biologically aggressive and "mimic relatively well" the "clinical situation". Orthotopic grafting are better than s.c. ones because the tumor microenvironments are very different in the skin and in the lung.
However, we are also using this kind of models s.c. for certain type of experiments.
See the attached articles.
Whatever it can be, you must never forget that a model is a model and nothing else. It is a tool to validate more or less strongly a scientific hypothesis, but it will never "represents" the clinical reality.
Best regards
Robert
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