Bock KW paper:Notably, phenobarbital and bilirubin are not ligands of CAR but activate CAR via phosphorylation/dephosphorylation pathways (Timsit and Negishi, 2007).
Bilirubin is a chemical dye produced in the liver, spleen. Bilirubin is an analysis in which the total amount of direct or indirect bilirubin is tested in the blood. Bilirubin is the result of the decomposition of hemoglobin, a protein in red blood. After red blood cells age, these cells break down and are eaten by adult cells , And then the hemoglobin protein is divided into "Hem" and "Globin". The "heem" molecule is converted into bilirubin and then transported to the liver and excreted through the liver through the gallbladder. Most bilirubin is associated with glucuronide, which is done before the gallbladder is released. Indirect bilirubin is not related to glucuronide, It is directly linked to glucocoronid. Bilirubin is then converted to gallbladder, then transformed into germs by the germs. It gives brownish feces, and a small part is secreted through the urine and transformed into europilinogen. The bilirubin surplus occurs in several areas such as the eye, skin, and mucous membranes, causing jaundice, as jaundice becomes apparent when it reaches | The increase in the percentage of bilirubin in the blood to more than (2.5) mg per 100 ml; as the increase of the proportion of Albilibubin direct lead to the darkening of the color of urine, which is distributed through the urine and the rise in the proportion of bilirubin in the serum after gallbladder disease to excrete white and colorless stools , As bilirubin does not reach the intestine, and at times jaundice is accompanied by itching, and that is not healthy and sound, in the case of jaundice must be reviewed by the doctor.