We posit that, by virtue of its location in the ER/SR and Golgi networks in skeletal muscle, and the finding that some dysferlin mutations are associated with ER stress, dysferlin is likely to be involved in protein processing and trafficking.
Article Improved immunoblotting methods provide critical insights in...
Christian Q. Scheckhuber
Some studies indicates that dysferlin may bind lipids in a calcium-dependent manner, consistent with a role for dysferlin in regulating fusion of repair vesicles with the sarcolemma during membrane repair ( please see this article: http://www.ncbi.nlm.nih.gov/pubmed/24461013 ). However, how dysferlin achieves a 're-closure' of the membrane is not clear yet...
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