I would like to test my contrast agent and measure relaxation testing with mri. MRI is cheaper but they have a long queue and the concentration used is higher than in NMR. but I never used NMR before, what is the difference between T1 T2 and susceptibility measurement performed with NMR?
In theory, it sounds like NMR can acquire even more information that MRI, but is it applicable for actual real-life application. Contrast agent is functionalized metal-based nanoparticles.
You basically get the same result. The difference will most likely result from the different magnetic field strength. Then you have to make sure that your contrast agent does not exhibit field dependent T1, T2 or susceptibility.
Clemens Anklin thank you very much for helpful comment. Is there any way to tune down the field in NMR? or is there any other way on how to make sure CA is not field dependent?
This is an interesting question. In theory - yes, T1 and T2 data measured in conventional NMR may be used for rough estimation of relaxation times in MRI investigations. However, both T1 and T2 do not depend only on the internal molecular structure; both may change in different environment (for example, the presence of paramagnetic impurities may reduce relaxation times dramatically).
Considering the difference in conditions between conventional high-resolution NMR vs MRI, it would be interesting to hear the comments regarding this issue in real life applications.
Dear Stefan,
to my limited (NMR) understanding MRI contrast reagents are chracterized by their RELAXIVITY which is the influence on their presence on the T1 or T2 RELAXATION of water in their spatial proximity....this effect will depend on viscosity of the matrix and the field strength but a "trend" found in NMR and MRI will be comparable.
Maybe there is a "phantom solvent" (to my remembering glycerol of high conc in water) you can use in a NMR tube.
You may want to take a look at
Article Field strength and dose dependence of contrast enhancement b...
Cheers and kind regards
Alfred
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