I want to extract heavy metals from goat visceral organs and establish biomarkers to identify metals.
toxic metal may cause various pathological disorders in those with metal overdose.liver and kidney disease are among them.
Heavy metals such as Cd, Hg and Pb will accumulate in organs - kidney and liver, as well as in muscle. I'm not quite sure what you mean by wanting to establish biomarkers, but in man the established 'test' is a blood level (hair and nails are also used but not ideal). Bone levels can give you information about longer term exposure.
Dear Ekele
There are a few papers that you can find them at
http://www.ijer.ir/?_action=article&keywords=+histopathological
Heavy metals such as Cd ,Hg and Pb can be extracted from the visceral organs of goat through : Dry Ashing or through the chemical digestion of the organic matter by using perchloric acid ,nitric or sulfuric acid .Heavy metals induce severe destructive pathological changes represented by vacuolar ,hydropic degeneration and coagulative type of necrosis in liver ,kidney etc .Regarding the lead toxicosis , an intranuclear eosinophilic inclusions can also be detected .
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