P. aeruginosa is uniquely problematic because of its biofilm forming ability, also, the ease with which drug-resistant plasmids are transfered in a cellular community is another contributing factor.
Drug resistance and biofilm forming abilities are two important factors. They can colonise most of the articles.. even some of the antibacterial agents.
One of the most frequent agent for nosocomial infection.
It depends in which context you are asking the question. If related to human health then the explanations above are good ones. Pseudomonas can be a significant issue in the water systems of healthcare facilities (causes a large proportion of health-care associated infections). Can colonise healthy patients but be easily spread (hands, water, surfaces, indwelling medical devices etc.). Have a look at the outbreaks in Belfast NICUs in 2012 and several others since.
It depends in which context you are asking the question. If related to human health then the explanations above are good ones. Pseudomonas can be a significant issue in the water systems of healthcare facilities (causes a large proportion of health-care associated infections)
What does make P. aeruginosa uniquely problematic?. Available from: https://www.researchgate.net/post/What_does_make_P_aeruginosa_uniquely_problematic [accessed May 8, 2017].
What makes P. aeruginosa uniquely problematic is a combination of the following: the species' inherent resistance to many drug classes; its ability to acquire resistance, via mutations, to all relevant treatments; its high and increasing rates of resistance locally; and its frequent role in serious infections. A few isolates of P. aeruginosa are resistant to all reliable antibiotics, and this problem seems likely to grow with the emergence of integrins that carry gene cassettes encoding both carbapenemases and amikacin acetyltransferases.