I have some personal experience (not scientific evidence) in this field. We use the injections of  autologous platelet rich plasma or bone marrow supernatant in such cases for many years. Conclusion - sometimes it works. We use it as a last resort when only amputation is an option. The effect usually develops several months after injections, so this method is not optimal for progressing necrosis or untreatable rest pain.

We also were performing the method by using the aspiration of bone marrow for many cases. Obviously, it was not inducing miracles. (emprically)

Adipose tissue is told to be a rich source for pluripotent stem cells. And the method is really feasible. (local + tumescent anesthesia for liposuction). I tried it for 3 patients (just wihin 2 weeks)  and wanted to know your experiences. 

Regards.

Dear Cemal ,

I think that`s a possibility.I believe in angiogenic therapies for critical limb ischemia .

See the attached publication.

I conducted Autologous Adipose Derived Stem Cell (AADSC) application in thirty-four patients. Most of them had Buerger Disease and the rest had inoperable distal arterial occlusive diseases. In both groups, including local distal phalangeal necroses, we obtained good results. I personally think that, this method has a promising future. However, clinical evidence and the statistical data are not sufficient so far. But, it often elongate the claudication distance and providing increased comfort to these patients. If anyone interested, I can send the before-after photos of the ischemic limbs!

Dear Başbuğ,

Thanks for sharing your experience and series. i'd love to see a few demonstrative pics from your cases.

Best Regards.