I observed growth inhibition/cell arrest coupled with cell migration at the same time during treatment of drug X that activates MAPK signaling.
Why are cancer cells arrested before they could migrate?
Are these cells preparing themselves (preparation phase?: attain enough signals, morphological alternation etc. ?) so that they could migrate easily?
Reference to your input will be highly appreciated.
#metastasis #Cancer #Hepatoma #signaling
this is a well known pehmomenon. here just two example in melanoma:
Article Wnt5A promotes an adaptive, senescent-like stress response, ...
Article A slow-cycling subpopulation of melanoma cells with highly i...
Michela
Tumors are very heterogeneous genetically, phenotypically and metabolically. With clonal evolution you have more than one kind of cells that evidently behave differently.
If all the cells would be equal, chemotherapy would solve all cancers. It does not.
In your case you have two different kind of populations.
probably you have two different status in your cell line. epithelial mesenchymal transition and mesenchymal epithelial transition. the first status arrest in G2 cell cycle and the second one acquire the invasive characteristics.
Mohammad Rafiee Monjezi Why is there two different status?
Adaptive stress response hypothesis and Clonal evolution theory of cancer cell totally explain the phenomena.
Thank you Michela Perego Tomas Koltai for your valuable input
I just mention that its possible in invivo, but in this case you may simulate in vivo events by triggeing mapk signalig and their hetrogencity lead to different response to same stimulation. What do you think?
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