I am currently trying to follow a synthesis protocol as follows :
· To a flask were added 175 ml benzene, 18.1 g (0.18 mol) 3-Aminobutanoic acid, 40.0 g (0.21 mol) p-toluenesulfonic acid (monohydrate), and 87.5 ml (0.80 mol) benzyl alcohol.
· The mixture was refluxed and evolved water was removed by azeotropic distillation using a Dean and Stark trap.
· The resultant liquid was poured into a mixture of 280 ml diethyl ether and the same amount of hexane.
· Precipitates were separated and washed with diethyl ether.
Then, the crude sample was purified by recrystallization from a mixture of 600 ml diethyl ether and 150 ml ethanol to afford 53.78 g of (1) as a white powder (yield 79.7%).
In the literature, they used benzene as the solvent. Can I use Toluene instead of benzene here for the azeotropic distillation?
Here is the link to the article
https://www.tandfonline.com/doi/epdf/10.1163/156856200743526?needAccess=true&role=button
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