For repair of DNA double strand breaks (DSBs) by homologous recombination, ATP dependent DNA strand exchange takes place whereby a template strand invades base-paired strands of homologous DNA molecules. RAD51 aids the search for homology and strand pairing in this process. RAD51 paralogues are thought to act in homologous recombination for repair of DNA double strand breaks (DSBs) by stabilizing or destabilizing the RAD51 filament for recombination. Is there strong evidence for any other roles?
RAD51C was the responsible gen to diagnose a Fanconi Anemia patient and now is also named FANCO. Fanconi Anemia Pathway is the main pathway involved in DNA interstrand cross-links (ICLs) repair. That repair is dependent on replication. There are a lot of papers around.
RAD51 paralogues are responsible for changing the RPA protein associated with ssDNA tails to RAD51 protein, it are one of the class of mediators involved in this changing.
I am not sure but you can look on Heyer and co-worker from 2010 published paper on HR topic, maybe you find more details about that.
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