I am curious as to the particular mechanisms by which exogenous antibody can induce protection. Considering these antibodies do not result in natural immunity, do they have limited functions in vivo? Do these antibodies have the ability to mediate CMI by interaction with innate host cells and receptors?
For example, do passively administered antibodies solely opsonize/neutralize pathogens? Are they able to engage FcyR similarly to endogenous antibodies? Are they able to function in complement fixation or ADCC?
I have had a hard time finding this information from online sources, as most give a general definition of passive immunization without any underlying mechanisms or differences in action.
I am most interested in this in the context of immunization with immune complexes. Would co-injecting antibodies improve cellular uptake of antigens? Would this potentially stimulate development of active immunity?
Given an immunogen that does not bind germline Abs well (such as HIV GP140), could co-administering broadly neutralizing antibodies initiate adaptive responses by effecting providing T-helper cells and naive B-cells with antigen? Could this potentially enhance formation of germinal centers, which would concentrate antigen and allow for more efficient recognition by rare, antigen-binding, naive B-cells?
Thanks for the input!
Passive immunisation involves introduction of prepared antibodies that may not last long in the body.
Dear...despite of the fact that these papered antibodies last for no long time, but they are highly effective as a fast management in protection against getting deadly infectious diseases like tetanus and rabies in the case of injuries and dog bites...simply these antibodies interact with Antigens and toxins (main virulence factors) and prevent them from reaching target tissues and cause infection..hence fast administration is an important factor for the success of passive immunity protocol.
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