What are the major issues when synthesizing molecular trefoil knots for chiral chromatography sorbents?

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Marius Kroll

Hi Paul,

the problem here are the horrible yields and long synthesis routes. Check 10.1002/anie.201105012 for more info.

Greetings

Marius

Paul Karch

Marius,

Thank you for your quick reply... is this the same technology used with the Water's AMY Trefoil column?

Paul,

the Waters chiral columns are tris-(3,5-dimethylphenylcarbamate) modified amylose columns. The word trefoil is just a marketing name here.