Hello
Epithelial to Mesenchymal Transition (EMT) describes a mechanism by which cells lose their epithelial characteristics and acquire more migratory mesenchymal properties. This transient and reversible process can be classified into three subtypes, depending on the biological and functional setting in which it occurs. Type 1 EMT underlies the generation of secondary epithelia and is critical during embryogenesis and organ development. Type 2 EMT materialize in the interstitial spaces between developing secondary epithelium and endothelium that these tissues are primed for an inducible fibrogenic response consequent to persistent inflammation. Fibroblast formation and fibrosis, therefore, are principally a feature of immunologic and tissue maturation, while type 3 EMT is characterized by the transformation of epithelial cells into the invasive metastatic mesenchymal cells that underlie cancer . this type of ETM cells ready for movement, invasion, and metastasis . therefor , i want ask about what are the identities signals which transformation the Epithelial Mesenchymal Transition (EMT) to the invasive metastatic mesenchymal cells ? and , How cells respond to the change in the signals ?!
Regards
http://www.nature.com/nrm/journal/v15/n3/full/nrm3758.html
http://www.nature.com/nrm/journal/v7/n2/full/nrm1835.html
www.thoracic.org.au/.../monwf10845wdanial.pdf
Hello prof . saleh
Really very interesting question , I would also to know the explanation that.
Hi Pr Saleh
I think part of the answer is already in your question.
In order to go to a metastatic state cells needs to become independent of the ECM attachment by lack of adhesion proteins production, or by ECM degradation by proteinases (MMPs) produced either by cells themselves or by TAMs (tumor associated macrophages) M2 polarized.
here is some papers among others
Expression of c-ets-1 mRNA is associated with an invasive, EMT-derived phenotype in breast carcinoma cell lines.
Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression.
Hope it helped a little
Regards
TGF-beta is central to EMT despite other factors chip-in. Article Classical epithelial-mesenchymal transition (EMT) and altern...