The association of free radicals in the pathophysiology of chronic diseases like degenerative brain disorders (AD, PD, HD, Stroke) has been evident by a substantial research.
Thank you Gabriel Godson Akunna for the pdf file. But unfortunately I could not open this file. Could you please give me the direct link, if there is available online.
The answer to your question is presented in our articles, as in 1997 ( Liu Shusen, Bioscie. Repot,17, ),1999 ( Jour. Biomemb. & Bioenerg.,31 ) and 2010 (AnnN.Y.Acad.Sci.,1200 ).
Causes of Reactive Oxygen Species /a.k.a. Free Radicals . Please check sources of unpaired electrons which will generate excess ROS thus adversely affecting myelin, axons, microtubules and more. High Gradient Magnetic Fields, Solar Flares, remanent magnetism in certain types of rock (paleomagnetism) and EMFs from many types of electronic equipment. Remember the Carrington Event in 1855 which sent extremely strong EMFs down copper wiring for telegraph users in Europe and Americas all from massive Solar Flare. Compass needles were seen to spin !! MS and MND cases triggered - read Prof Charcot - Paris papers at that time. Also look at human spinal cord as unintentional antenna for MHZ and GHz signals - and L'Hermittes sign.