Tumor cells could have altered depolarizing membrane voltage relative to surrounding normal cells.
This is a very good question. There is a clear difference of membrane potential between cancer and normal cell. Whereas cancer cells have more negative membrane potential normal cells have less than that.
Dear Sugumar,
Please visit the profile of Dr. Harald Sontheimer (registered on RG).
You will find precise responses.
Best regards
Robert
Please see link. This might help.
http://www.royalrife.com/haltiwanger1.pdf
there are very fundamental differences.first the level of Vm and second is the alteration of Vm during the cell cycle, third is the behavior and expression of ions channel.there are many differences if you wonder message me to send some references
[1]. Binggeli, Richard, and Ivan L. Cameron. "Cellular potentials of normal and cancerous fibroblasts and hepatocytes." Cancer research 40.6 (1980): 1830-1835.
[2] . Yang, Ming, and William J. Brackenbury. "Membrane potential and cancer progression." Frontiers in physiology 4 (2013): 185.
Really good reads. I myself am exploring this fundamental aspect of cells at my institution. Fascinating world.
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