What are the effects of adding too much catalyst in a suzuki reaction? I seem to be getting a majority of the mono coupled product and recovering starting material enough though I add an excess of the borylated agent.
Additional catalyst shouldnt hurt the reaction. What are your coupling partners And reaction conditions?
Homocoupling usually suggests presence of oxygen.
Where does the Cu come from? Ajeet Singh
Di-brominated electron-deficient benzene and a borylated benzene with OH @Greg Petruncio
Try protecting your OH group with a benzyl protecting group (OBn). Suzuki coupling is run under basic conditions and so the acidic phenol is probably interfering with your reaction.
Miss/Mrs Y. Choaie,
As Mr. Greg suggested, it is obvious that excess addition of catalysts may result in undesirable products for the substrates/ reactants with multiple like/ alike functional groups. So, I sincerely suggest you to go with catalysts optimization. In your case one substrate is with two bromine atoms and the other substrate with hydroxy group. So, there are every chance for competition among two bromine atoms for suzuki coupling and on other side for ether formation among bromine and alcohol.
Dear Yasmin ,
check the link below
https://pubs.rsc.org/en/content/articlelanding/2019/nj/c9nj04491d
I hope this information will be useful to you
Mohamed
The reaction selectivity may found to depend on the amount of the base used
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