What are the characteristics of peptide drugs that cross the blood-brain barrier?

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Adam B Shapiro

Here are a few reviews on that subject:

Article Peptides and the Blood-brain Barrier.

Article Penetration of the blood-brain barrier by peripheral neurope...

Maurice Ekpenyong

Peptide shuttles formed by 2–4 amino acid residues that cross the BBB through passive diffusion are more attractive since they may minimize the loss of activity upon conjugation. For details see the attached Article Blood-brain barrier shuttle peptides: An emerging paradigm f...

Hoorie sadat Sabet

Adam B Shapiro thank you soooo much dear :)

Maurice Ekpenyong I want to design a peptide with about 8-9 amino acid. now i have an obstacle about cross it from blood brain barrier, because of it's molecular weight that must be 400-600 Da. Based on what you know, Can it cross?

Marios Charalambous

hi, thank you for your help, but can I test this route for TBI rats?