What are the best markers for evaluating the immunological effects of massive allogenic blood transfusion?

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Dharmesh Chandra Sharma

Dear Olayanju

I think ICT (Indirect Coombs Test ) & DCT (Direct Coombs Test) on serum and RBCs respectively are initially the best markers for evaluating the immunological effects of massive allogenic blood transfusion.

all the best

Musa Abidemi Muhibi

To assess cumulative immunological effects of massive transfusion, you may quantity IgG levels among massive transfusion recipients and a control group, within the population. A comparison of the data generated may be helpful in your research. Thanks

Muttuswamy Sivakumaran

In addition to the red cell antibodies (ICT and DCT as suggested by Dharmesh), you may also want to check HLA antibodies especially if the blood units were not leucodepleted. Good luck.

Siva